TABLE 1.
Arterial plasma levels of norepinephrine, epinephrine and cortisol before (control) and after drug treatment (Test Period I) and subsequent increase of plasma glucagon (Test Period II) in 18-h fasted conscious dogs
Values are means ± S.E. for five experiments. V, vehicle.
| Hormones | Groups | Control (0 min) | Study Periods |
|||
|---|---|---|---|---|---|---|
| Test Period I |
Test Period II |
|||||
| 60 min | 90 min | 150 min | 210 min | |||
| Norepinephrine (pM) | V | 673 ± 59 | 682 ± 118 | 532 ± 127 | 751 ± 136 | 790 ± 129 |
| GPI | 523 ± 138 | 489 ± 142 | 488 ± 105 | 519 ± 175 | 689 ± 189 | |
| MT | 761 ± 227 | 592 ± 184 | 697 ± 245 | 767 ± 250 | 871 ± 291 | |
| Epinephrine (pM) | V | 345 ± 144 | 383 ± 160 | 237 ± 110 | 315 ± 101 | 535 ± 230 |
| GPI | 332 ± 152 | 658 ± 373 | 509 ± 157 | 350 ± 157 | 624 ± 317 | |
| MT | 824 ± 277 | 527 ± 215 | 713 ± 248 | 589 ± 204 | 520 ± 245 | |
| Cortisol (nM) | V | 62 ± 12 | 41 ± 5 | 54 ± 18 | 58 ± 8 | 46 ± 4 |
| GPI | 79 ± 16 | 101 ± 31 | 83 ± 19 | 96 ± 22 | 95 ± 24 | |
| MT | 69 ± 6 | 87 ± 19 | 84 ± 12 | 94 ± 22 | 97 ± 10 | |