FIG. 5. Improvement in the number of knots tied between the first and second training/repetition sequence. A comparison of the improvement (in average number of knots tied by preclerkship medical students) between the first and second training/repetition sequence in both the computer-based self-directed learning group and the didactically trained group. A significant ( p < 0.04) difference was observed. Error bars correspond to the standard error of the mean shown.