Fig. 2.

Rapamycin rescues preterm birth in mice deleted of uterine p53 (p53^d/d). (A–C) Preterm birth (deliveries earlier than day 19) and neonatal deaths in p53^d/d mice are rescued by an oral gavage of an mTORC1 inhibitor rapamycin (0.25 mg/kg body weight/day) on days 8, 10, and 12 of pregnancy. In A, numbers in parentheses denote the ratio of dams with preterm birth/total dams. In B, day of deliveries are shown with numbers of animals examined indicated within the bars. In C, numbers in parentheses denote the ratio of dead pups/total pups. Values are mean ± SEM. *P < 0.05 vs. vehicle-treated p53^f/f; **P < 0.05 vs. vehicle-treated p53^d/d. (D) Number of viable fetuses in p53^f/f or p53^d/d females treated with vehicle or rapamycin. Values are mean ± SEM. P > 0.05.