Fig. 4.

Superimposition of p21 deletion on uterine deficiency on p53 rescues preterm birth and neonatal deaths. (A) Number of fetuses in p53^f/f, p53^d/d, p21^d/dp53^f/f, and p21^d/dp53^d/d females on day 16 of pregnancy. Values are mean ± SEM. P > 0.05. Numbers inside the bars indicate the number of mice examined. (B–D) Preterm birth (delivery earlier than day 19) was not observed in p21^d/d p53^d/d females. In B, numbers in parentheses denote the ratio of dams with preterm birth/total dams. In C, days of delivery are shown with numbers of animals examined indicated within the bars. In D, numbers in parentheses denote the ratio of dead pups/total pups. Values are mean ± SEM. *P < 0.05 vs. p53^f/f; **P < 0.05 vs. p53^d/d.