Fig. 1.
The landscape to conceptually describe the behavior of the synthetic diversification system and the network diagram of the synthetic circuit for the diversification. (A) Landscape. The horizontal axis to the landscape represents the cell state indicating the cellular concentration of LacI. The vertical axis to the landscape represents the AHL concentration. (B) Network diagram. CIts and LacI mutually inhibit each other. The Plux/lac promoter, which regulates CIts, can act as a Plac promoter with sufficient AHL. (C) The high-state cells (Left) produce AHL at a much higher rate than the low-state cells (Right).