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. 2011 Oct 24;108(44):18044–18048. doi: 10.1073/pnas.1113395108

Fig. 1.

Fig. 1.

Ig gene features of IgG-positive plasma cells. Ig gene repertoire and Ig gene features of IgG plasma cell antibodies from four HDs (HD15, HD16, HD20, and HD21) are shown in comparison with historical data from IgG memory B cell antibodies (5, 7). VH/JH gene family use and IgH CDR3 amino acid-positive charges and length (A) and Vκ/Jκ and Vλ/Jλ gene family use (B) and IgG subclass distribution (C) are shown. Pie charts show the data for individual HDs with the absolute number of sequences analyzed indicated in the pie chart center. Bar graphs compare the data obtained from IgG plasma cell antibodies (n = 238; κ, n = 147; λ, n = 97) to historical data from IgG memory B cell antibodies (n = 254; κ, n = 172; λ, n = 83) (5, 7). Error bars indicate SD. (D) Dots represent the absolute number of somatic mutations (nucleotide exchanges compared with the nearest germline gene segment) in individual IgH and IgL Vκ and Vλ genes in IgG plasma cell antibodies from all four HDs. Horizontal lines indicate averages.