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. 2011 Oct 24;108(44):18144–18149. doi: 10.1073/pnas.1108416108

Fig. 1.

Fig. 1.

Exploration and ambulation in Myk/+ mice. Myk/+ show an increased number of explorations of (A) novel objects (+/+ mice n = 10, Myk/+ n = 11) and (B) nosepokes compared with +/+ mice and do not habituate (+/+ mice n = 8, Myk/+ n = 7). (C) In an open field Myk/+ travel a further distance and (D) spend more time in the center (+/+ mice n = 27, Myk/+ n = 22) in 5-min bins compared with +/+ mice. (E) Myk/+ exhibit unusual walking patterns compared with +/+ mice. (F) In 60 min in the open field, Myk/+ increase locomotor activity in response to d-amph, but +/+ mice do not (+/+ vehicle n = 9, +/+ d-amph n = 9; Myk/+ vehicle n = 8, Myk/+ d-amph n = 9). All data are presented as mean SEM, *P < 0.05, **P < 0.01, ***P < 0.001 compared with +/+ mice, ###P < 0.001 compared with Myk/+ vehicle mice.