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. 2011 Oct 24;108(44):18144–18149. doi: 10.1073/pnas.1108416108

Fig. 2.

Fig. 2.

Sleep and endogenous circadian period in Myk/+ mice. (A) Myk/+ (n = 6) experience more wake time than +/+ mice (n = 6) across 24 h with a reduction of both non-REM and REM sleep, as assessed by EEG and EMG. (B and C) Myk/+ show deficits in sleep duration only during the light phase; (D) Myk/+ have fewer REM sleep bouts but no change in non-REM bouts. (E) Non-REM bout length is reduced and REM bout length was unchanged in Myk/+. (F) REM sleep latency is reduced in Myk/+. (G) Wheel running actograms from +/+ and Myk/+ mice. Animals were held on a light-dark (LD) cycle for 14+ d, released into constant dark for 7 d to assess free running period, and reentrained to a LD12:12 cycle. Shaded area represents dark portion of LD cycle. Vertical arrows indicate continuation of nocturnal activity into light. (H) Endogenous period is extended in Myk/+ because of longer periods of (I) activity (α). All data are presented as means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001 compared with +/+ mice.