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. 2011 Oct 24;108(44):18144–18149. doi: 10.1073/pnas.1108416108

Fig. 4.

Fig. 4.

Attenuation of mania-like behavior by lithium and VPA in Myk/+ mice. (A) Chronic treatment with lithium reduces total distance traveled by Myk/+ (n = 20) compared to untreated Myk/+ (n = 22) over 30 min in the open field and had no effect in +/+ mice (n = 28 control, n = 27 lithium). (B) VPA reduced total distance traveled by Myk/+ (n = 20) compared to vehicle-treated Myk/+ (n = 22), and had no effect on +/+ mice (n = 28 vehicle, n = 27 VPA) over 30 min. (C) Lithium reduces open-arm duration in Myk/+ (n = 18) compared with control Myk/+ (n = 19), but had no effect on +/+ mice (n = 29 control, n = 29 lithium) in the EPM. (D) VPA reduces open-arm duration in Myk/+ (n = 12) compared with vehicle-treated Myk/+ (n = 10) but had no effect on +/+ mice (n = 12 control, n = 12 VPA) in the EPM. (E) ERK inhibitor SL327 decreased distance traveled in Myk/+ (n = 12) compared with vehicle-treated Myk/+ (n = 9), and had no effect in +/+ mice (n = 12 vehicle, n = 12 SL327) in the open field. (F) SL327 reduced open-arm duration in Myk/+ (n = 6) compared with Myk/+ vehicle (n = 6) but had no effect on +/+ mice (n = 6 control, n = 6 SL327) in the EPM. (G) Rostafuroxin decreased distance traveled in Myk/+ (n = 12) compared with vehicle treatment (n = 12) and had no effect in +/+ mice (n = 13 vehicle, n = 15 rostafuroxin) in the open field. (H) In the EPM rostafuroxin reduced open arm duration in Myk/+ (n = 12) compared with vehicle treated Myk/+ (n = 12) and had no effect in +/+ mice (n = 12 vehicle, n = 15 rostafuroxin). All data are presented as means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001 compared with +/+ mice, #P < 0.05, ##P < 0.01, ###P < 0.001 compared with Myk/+ vehicle mice.