Table 2.

Animal Data by Group

Group	Number of Animals	Age Mean (Range)*	Species	Sex	Eye Status	IOP at Baseline Mean (Range)	EEG Eye Post-laser Maximum IOP Mean (Range)	Cumulative IOP Difference†	IOP during Perfusion Fixation	Pre-euthanatization IOP Elevation Time (mins)
N10 - N10	6	7 (2–10)	R	3M/3F	N OD	12 (8–14)	N/A		10 mm Hg	N/A
					N OS	11 (8–14)	N/A	N/A	10 mm Hg	N/A
N30/45 - N10	6	7.5 (5–14)	5R/1C	5M/1F	N OD	9 (4–12)	N/A		30 or 45 mm Hg	15 or 30
					N OS	9 (4–12)	N/A	N/A	10 mm Hg	N/A
EEG10 - N10	3	10 (8–11)	C	M	N	10 (8–11)	N/A		10 mm Hg	N/A
					EEG	9 (9–10)	28 (20–37)	221 (116–360)	10 mm Hg	N/A
EEG30/45 - N10	6	8 (5–11)	4R/2C	M	N	10 (8–13)	N/A		10 mm Hg	N/A
					EEG	11 (8–14)	28 (16–38)	295 (50–807)	30 or 45 mm Hg	15

Animals in this study aged 7 (3 ∼ 14; 16 young adults, 5 adults) during their period of study and aged 8 (3 ∼ 14; 8 young adults and 13 adults) at the time of euthanatization. We defined young adults from age 3 to 8 and adults from 8 to 18. Axon loss for EEG10 - N10 monkeys ranged from 16 to 30%.⁶ R, rhesus; C, cynomolgus; M, male; F, female; N/A, not applicable.

^*Age at euthanatization.

^†Cumulative IOP Difference is the difference in area under the IOP-time curve between the EEG and normal eye (units mm Hg days).