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. 2011 Nov 3;6(11):e24709. doi: 10.1371/journal.pone.0024709

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Mankoo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Different modules are spatially separated for visualization. The genes present in our signature are shaped as octagons (mRNA features), diamonds (methylation features) and rectangles (copy number feature). The linker nodes are represented as small circles. Nodes are colored based on the mRNA expression profile of different genes (green: down-regulated in short recurrence patients (PFS<6mo) compared to long recurrence (PFS>40mo), and red: up-regulated).