Table 4. The anti-hyperlipidemic action of MGO is associated with camphene.
Rat Group | Percent change | |||||
Plasma lipid | (A) | (B) | (C) | (D) | +Mixture | |
content (mg/dl) | Placebo | Triton WR-1339 | +Mixture A | +Mixture B | A | B |
+Triton WR-1339 | +Triton WR-1339 | |||||
Total cholesterol | 65.1±6.9 | 262.9±32.3 | 263.4±23.7ns | 156.7±12.3*** | +1.2 | −40.4 |
LDL-cholesterol | 16.4±2.8 | 47.6±9.1 | 45.4±10.7ns | 18.5±2.7*** | −4.7 | −61.1 |
Triglycerides | 130.2±22.6 | 1950.8±191.1 | 1976±140.7ns | 888.7±99.3*** | +1.3 | −54.4 |
The placebo group (A) was administered 1 ml carrier alone. The Triton WR-1339 group (B) was administered 1 ml carrier and one h later 1 ml of Triton WR-1339 (200 mg/kg). Animals in (C) and (D) received Mixture A and Mixture B, respectively, in 1 ml carrier and one hour later received Triton WR-1339. Mixture A consisted of α-pinene, β-pinene, myrcene, β-caryophyllene and linalool; and Mixture B consisted of Mixture A+camphene. The constituents in Mixtures A and B were present at concentrations identical to those contained in the 4% MGO dose. The percent change caused by Mixture A and B treatments is expressed relative to measurement in the group of Triton WR-1339-treated rats (B), which was defined as 100%. The values represent mean ± SD of six rats. Significantly different values were obtained in Mixture B-treated rats compared to Triton WR-1339-treated rats with p<0.001 (***) by the Student-Newmann-Keuls test. Values of Mixture A-treated rats vs Triton WR-1339-treated rats were non significant, ns (p>0.05).