Table 5. Effect of various camphene concentrations on contents of total cholesterol, LDL- cholesterol and triglycerides in the plasma of Triton WR-1339-treated rats.
| Rat Group | |||||
| Camphene | Plasma lipid | (A) | (B) | (C) | Lipid decrease |
| dose per | content (mg/dl) | Placebo | +Triton WR-1339 | +camphene | in rat group (C) |
| body weight | +Triton WR-1339 | compared to | |||
| (µg/g) | rat group (B) (%) | ||||
| 1.5 | Total cholesterol | 68.3±12.9 | 280.4±21.5 | 226.0±18.5*** | 19.4 |
| 1.5 | LDL-cholesterol | 12.9±3.4 | 49.4±6.1 | 36.4±6.8** | 26.3 |
| 1.5 | Triglycerides | 124.5±28.0 | 1920.5±197.8 | 1481.5±219.5*** | 22.9 |
| 7.5 | Total cholesterol | 70.3±6.2 | 342.1±27.6 | 231.2±16.1*** | 32.4 |
| 7.5 | LDL-cholesterol | 14.2±2.8 | 99.2±11.8 | 53.7±7.1*** | 45.9 |
| 7.5 | Triglycerides | 136.4±13.9 | 2875.0±180.7 | 2042.3±153.4*** | 29.0 |
| 30 | Total cholesterol | 72.0±9.1 | 529.1±85.8 | 240.8±22.5*** | 54.5 |
| 30 | LDL-cholesterol | 13.2±3.1 | 284.5±39.9 | 131.1±9.4*** | 54.0 |
| 30 | Triglycerides | 120.5±15.5 | 2443.6±126.0 | 1600.3±20.3*** | 34.5 |
The placebo group (A) was administered 1 ml carrier alone, whereas the Triton WR-1339 group (B) was administered 1 ml carrier and one h later 1 ml of Triton WR-1339 (200 mg/kg). The camphene treated group (C) received a dose of camphene and one h later a single dose of Triton WR-1339. Camphene was administered at 1.5, 7.5 and 30 µg/g of body weight. Controls and camphene were injected ip. Twenty-four hours later, blood was collected from the hearts of animals in heparinized tubes, and plasma samples were prepared and assayed for total cholesterol, LDL-cholesterol, and triglycerides. The values represent mean ± SD of six rats. Significantly different lipid contents were determined in the camphene treated rats (C) compared to rats treated with Triton WR-1339 alone (B). p<0.01 (**), and p<0.001 (***) by the Student-Newmann-Keuls test.