Table 1. Morphology of the spleens of 30- and 125-day-old SCID and NMRI nude mice.
Mouse strain | Provider | Suitable for IS injection at age of30 days | Suitable for IS injection at age of 125 days | Mice developing intrasplenic tumor (ratio) | Mice developing hepatic metastases (ratio) |
SCID | Charles River (Sulzfeld, Germany) | No | No | NA | NA |
SCID | Harlan (Horst, Holland) | No | No | NA | NA |
SCID | Taconic (Lille Skensved, Denmark) | No | Yes | 20/20 (100%) | 20/20 (100%) |
NMRI-nu/nu | Charles River (Sulzfeld, Germany) | Yes | Yes | 3/7 (43%) | 3/7 (43%) |
NMRI-nu/nu | Scanbur (Sollentuna, Sweden) | Yes | Yes | 2/4 (50%) | 2/4 (50%) |
SCID, severe combined immunodeficiency; NA, not applicable.