Table 3.
Replication of the 5 significant loci in the WOSCOPS trial and CARE study in association with baseline LDL cholesterol levels
| WOSCOPS N = 431 |
CARE N = 751 |
|||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Gene | Chr. | beta | se | p-value | beta | se | p-value |
| rs445925 | APOE APOC1 | 19 | 0.07 | 0.05 | 0.164 | -0.10 | 0.04 | 0.006 |
| rs6511720 | LDLR | 19 | -0.03 | 0.05 | 0.657 | -0.03 | 0.03 | 0.411 |
| rs258494*1 | HMGCR | 5 | 0.06 | 0.03 | 0.044 | 0.03 | 0.02 | 0.147 |
| rs174541*2 | FADS2 FEN1 |
11 | -0.04 | 0.03 | 0.264 | -0.03 | 0.02 | 0.134 |
| rs602633*3 | PSRC1 CELSR5 |
1 | -0.09 | 0.04 | 0.026 | -0.05 | 0.02 | 0.035 |
* A proxy for this SNP was used in both replication cohorts, for 1 the proxy SNP was rs7715806 with a r2 of 0.93, for 2 the proxy SNP was rs174545 with a r2 of 0.90, and for 3 the proxy SNP was rs660240 with a r2 of 0.88.
Abbreviations: SNP, Single Nucleotide Polymorphism; Chr, Chromosome.