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. 2011 Nov 3;7(11):e1002350. doi: 10.1371/journal.ppat.1002350

Figure 8. Transmission of TgMHu2ME199K prions to wt mice: pathology.

Figure 8

a: Frontal cortex sections of mice infected with RML or with TgMHu2ME199K prions on a wt or ablated background, analyzed for prion pathological properties, spongiosis, gliosis, and disease related PrP immunoreactivity with pAb RTC and mAb 6H4. Scale bar in upper left image indicates 50 µm. b: RTC immunoreactivity in the absence of formic acid for brains infected with TgMHu2ME199K/wt or RML, as well as for naïve PrP ablated mice. Picture shows different pattern of immunoreactivity for both infected samples. Scale bar in upper left image indicates 20 µm.