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Schematic comparison of human and rabbit CECs cell proliferation pathway stimulated by FGF-2. ERK1/2 pathway activated by PI 3-kinase increase cell proliferation through phosphorylation of p27 at both Ser10 and Thr187 residues in response to FGF-2 stimulation in hCECs. In contrast, parallel ERK1/2 and PI 3-kinase pathways induced by FGF-2 increase cell proliferation in rCECs.
