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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Cancer Prev Res (Phila). 2011 Jul 27;4(11):1884–1894. doi: 10.1158/1940-6207.CAPR-11-0221

Figure 3.

Figure 3

Effects of ISC-4 on Phase I metabolism of NNK by A/J mice microsomes. A, metabolism of 3H[NNK] by liver microsomes at time points 0, 0.5, 2, 4, 8, 16, 24, and 72 h post ISC-4 administration (1.25 µmol in 100 µl corn oil IG). B, metabolism of 3H[NNK] by lung microsomes at time points 0, 4, 8, 12, 16, 24, and 72 h post ISC-4 administration (1.25 µmol in 100 µl corn oil IG). C, effect of in vitro incubation of ISC-4 on control liver microsome metabolism of NNK to keto acid. D, effect of in vitro incubation of ISC-4 on control liver microsome metabolism of NNK to keto alcohol.