Table 1.
Genotyped Mouse Phase I and Phase II Human Orthologs(50)
| Phase I - Cyp | Phase II - Ugt | Phase II - Gst | |||
|---|---|---|---|---|---|
| Human | Murine | Human | Murine | Human | Murine |
| CYP2A6‡†, CYP2A7 | Cyp2a4,Cyp2a5 | UGT1A4* | Ugt1a5 | GSTA3 | Gsta3 |
| CYP2F1‡ | Cyp2f2 | UGT1A1 | Ugt1a1 | GSTA4 | Gsta4 |
| CYP2S1 | Cyp2s1 | UGT1A6 | Ugt1a6a | GSTP1 | Gstp1 |
| CYP4B1 | Cyp4b1 | UGT2B4 | Ugt2b1 | GSTM2 | Gstm2 |
| NF (2D6 superfamily)† | Cyp2c29 | NF | Ugt2b5 | GSTM3 | Gstm3 |
| NF (3A5 superfamily)‡ | Cyp3a11 | UGT2B10* | Ugt2b34 | GSTM1/M5 | Gstm1 |
| CYP8B1 | Cyp8b1 | UGT2B15 | Ugt2b35 | ||
| UGT2A3 | Ugt2a3 | ||||
| UGT1A9* | Ugt1a9 | ||||
| NF | Ugt1a10 | ||||
| UGT2B15 | Ugt2b36 | ||||
NF - no ortholog found
‡
Isoforms found to bioactivate NNK to keto alcohol
†
Isoforms found to bioactivate NNK to keto acid
*
Isoforms found to glucuronidate NNAL