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Methyl DNA adduct formation (pmol adduct/nmol G)
| Groups | Liver | Lung (pool) | ||
|---|---|---|---|---|
| O6-MG | 7-MG | O6-MG | 7-MG | |
| Untreated /Control Diet | n.d. | 0.29 +/− 0.04 | n.d | 0.56 |
| NNK Treated /Control Diet | 5.18 +/− 1.33 | 3.28 +/− 1.39 | 11.22 | 13.27 |
| NNK Treated/ ISC-4 Diet | 1.75 +/− 1.31† | 2.54 +/− 0.08 | n.d. | n.d. |
p = 0.0031 vs. NNK treated/Control Diet
n.d. - not detected
