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Western blot analysis of global acetylated H3 and acetylated α-tubulin proteins following the treatment of HCT116 cells with largazole 1 (L) and analogues at 10 nM, 100 nM and 1 µM concentrations after 24 hours of treatment. Increases of global acetylation were observed with largazole 1 at 100 nM and 1 µM and modest increases with analogues 27 and 28. α-tubulin levels remained unchanged.
