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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: J Immunol. 2011 Oct 5;187(10):5090–5098. doi: 10.4049/jimmunol.1100608

FIGURE 3. OVA-SP-induced tolerance is Treg-independent.

FIGURE 3

A, BALB/c mice (n=5) were treated with PC61 or control Ig i.p., tolerized, sensitized and challenged as shown. B, BAL eosinophils were quantified. C, IL-4, IL-5 and IL-13 in BAL supernatant were quantified by Milliplex. D Serum OVA-specific IgE was determined by ELISA. E and F, Mediastinal lymphocytes were restimulated with 25µg/mL OVA, (E) proliferation was quantified by [3H]TdR incorporation and (F) IL-4, IL-5 and IL-13 were quantified by Milliplex. Results are mean ± SEM and representative of three experiments. *p<0.05, **p<0.01, ***p<0.001.