Fig. 4.

Quantitative analysis of MRI data is still a research tool but it is becoming more apparent that these methods need to be translated into clinically efficient tools since measures of neuroanatomic abnormalities can be very useful as biomarkers for diagnosis and probably longitudinal monitoring. a The regional pattern of cortical thinning in PPA, shown here for a group of 23 PPA patients (including all three subtypes) vs. controls is highly asymmetric and localized in perisylvian regions of the language networks. b The map is generated from semi-automated measurement of the thickness of the cerebral cortex; comparison of the cortical thickness of a group of patients vs. a group of controls may reveal regionally specific thinning even though the magnitude of such thinning may be 0.1–0.2 mm