Fig. 6.

The three PPA subtypes are associated with distinct patterns of cortical atrophy. PPA-non-fluent/agrammatic patients exhibit primarily left prefrontal atrophy with relative sparing of temporal lobe cortex (left); PPA-semantic patients demonstrate anterior temporal lobe atrophy extending throughout much of the temporal lobe even early in the course (middle); PPA-logopenic patients show mainly caudal superior and middle temporal and inferior parietal atrophy early in the course of their illness