Table 3.
Family history of thyroid cancer in first-degree relatives in PTC cases and controls, by type of relative
| Type of relative | All patients
|
Women
|
Men
|
|||
|---|---|---|---|---|---|---|
| Case/Control 263/591 | Adjusted OR (95% CI) a | Case/Control 180/363 | Adjusted OR (95% CI) a | Case/Control 83/234 | Adjusted OR (95% CI) a | |
| First-degree relative | 18/8 | 4.6 (1.9–11.1) | 14/6 | 4.4 (1.6–12.2) | 4/2 | 5.3 (0.9–30.8) |
| Parent | 10/4 | 3.3 (1.0–11.0) | 9/3 | 3.4 (0.9–13.3) | 1/1 | 1.9 (0.1–32.6) |
| Sibling | 7/3 | 7.4 (1.8–30.4) | 5/3 | 5.9 (1.3–26.2) | 2/0 | - |
| Child | 1/1 | 2.4 (0.1–57.7) | 0/0 | - | 1/1 | 2.8 (0.2–49.8) |
| First-degree female relative | 14/7 | 4.5 (1.7–11.8) | 11/6 | 3.6 (1.2–10.4) | 3/1 | 9.9 (1.0–102.6) |
| Mother | 8/4 | 2.8 (0.8–9.7) | 7/3 | 2.9 (0.7–11.6) | 1/1 | 1.9 (0.1–32.6) |
| Sister | 5/3 | 5.9 (1.3–26.2) | 4/3 | 4.8 (1.0–23.1) | 1/0 | - |
| Daughter | 1/0 | - | 0/0 | - | 1/0 | - |
| First-degree male relative | 4/1 | 4.6 (0.5–42.9) | 3/0 | - | 1/1 | 1.7 (0.1–29.0) |
| Father | 2/0 | - | 2/0 | - | 0/0 | - |
| Brother | 2/0 | - | 1/0 | - | 1/0 | - |
| Son | 0/1 | - | 0/0 | - | 0/1 | - |
a
Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusted with age, sex, race, and number of first-degree family members (parents, sibling, children, as appropriate).