Table II.

Associations between MLL status and sex, race/ethnicity and age of diagnosis

	Leukemias				ALL				AML
	MLL−	MLL+	OR	95% CI	MLL−	MLL+	OR	95% CI	MLL−	MLL+	OR	95% CI
Sex
Male	77 (52.7)	103 (45.2)	1.00		44 (57.1)	72 (45.9)	1.00		33 (50.0)	31 (45.6)	1.00
Female	69 (47.3)	125 (54.8)	1.35	0.89 – 2.05	33 (42.9)	85 (54.1)	1.57	0.91 – 2.73	33 (50.0)	37 (54.4)	1.19	0.61 – 2.35
Race/ethnicity*
White	93 (63.7)	171 (75.3)	1.00		50 (64.9)	121 (77.6)	1.00		42 (63.6)	48 (70.6)	1.00
Black	14 (9.6)	7 (3.1)	0.27	0.11 – 0.70	7 (9.1)	4 (2.6)	0.24	0.07 – 0.84	7 (10.6)	3 (4.4)	0.38	0.09 – 1.54
Hispanic	21 (14.4)	31 (13.7)	0.80	0.44 – 1.48	11 (14.3)	17 (10.9)	0.64	0.28 – 1.46	8 (12.1)	13 (19.1)	1.42	0.54 – 3.76
Native American/Alaskan Native	4 (2.7)	1 (0.4)	0.14	0.02 – 1.23	1 (1.3)	1 (0.6)	0.41	0.03 – 6.74	3 (4.5)	0 (0.0)	--
Asian/Pacific Islander	8 (5.5)	12 (5.3)	0.82	0.32 – 2.07	5 (6.5)	10 (6.4)	0.83	0.27 – 2.54	3 (4.5)	2 (2.9)	0.58	0.09 – 3.66
Other	6 (4.1)	5 (2.2)	0.45	0.14 – 1.53	3 (3.9)	3 (1.9)	0.41	0.08 – 2.12	3 (4.5)	2 (2.9)	0.58	0.09 – 3.66
Age of diagnosis
≤3 months	35 (24.0)	64 (28.1)	1.00		13 (16.9)	47 (29.9)	1.00		22 (33.3)	14 (20.6)	1.00
4–6 months	31 (21.2)	75 (32.9)	1.32	0.74 – 2.38	11 (14.3)	56 (35.7)	1.41	0.58 – 3.44	18 (27.3)	19 (27.9)	1.66	0.66 – 4.20
7–9 months	37 (25.3)	58 (25.4)	0.86	0.48 – 1.54	19 (24.7)	35 (22.3)	0.51	0.22 – 1.17	18 (27.3)	23 (33.8)	2.01	0.81 – 4.99
10–12 months	43 (29.5)	31 (13.6)	0.39	0.21 – 0.73	34 (44.2)	19 (12.1)	0.16	0.07 – 0.36	8 (12.1)	12 (17.6)	2.36	0.77 – 7.21

ALL = acute lymphoblastic leukemia; AML = acute myeloid leukemia; CI = confidence interval; MLL− = no evidence of an MLL gene rearrangement; MLL+ = evidence of an MLL gene rearrangement; OR = odds ratio

^*Does not include 1 case with missing race/ethnicity.