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. Author manuscript; available in PMC: 2012 Nov 10.

Published in final edited form as: J Med Chem. 2011 Oct 10;54(21):7477–7485. doi: 10.1021/jm2005546

Table 2.

Summary of ion channel activity with the three major scaffold types

	EC₅₀ (µM)		IC₅₀ (µM)

				hNav1.5
Compound	3D7	K1	hERG	tonic	phasic	Kir6.2/SUR2A	TI (hERG IC₅₀/ K1 EC₅₀)
propafenone	2.69	0.92	2.88	3.3	>5	2.2	3
6z	0.06	0.10	2.6	N/A	N/A	N/A	26
6ch	0.13	0.005	4.84	>5	>5	>5	895
6k	0.39	0.18	4.31	>5	>5	>5	23
6b	0.09	0.05	3.46	>5	>5	>5	65