Table 1.
Demographic, functional, and neuropsychological data at first examination for bvFTD(CBD) group (N=5), bvFTD(Pick's) (N=5), and healthy older Normal Control group (N=53). Due to the small bvFTD group sizes, data are represented as median(interquartile range).
| bvFTD(CBD) | bvFTD(Pick's) | NC | ||||
|---|---|---|---|---|---|---|
| Med(IQR) | Range | Med(IQR) | Range | Med(IQR) | ||
| Sex (M/F) | 3/2 | -- | 4/1 | -- | 24/29 | |
| Education | 14.5(5.0) | 12 – 19 | 16.0(2.0) | 12 – 20 | 18.0(4.0) | |
| Age at symptom onset | 58.0(11.0) | 53 – 74 | 60.0(7.0) | 49 – 71 | n/a | |
| Disease duration at first exam (years) | 3.4(2.0) | 3.1 – 9.4 | 3.7(1.8) | 2 – 8.2 | n/a | |
| Disease duration at death (years) | 7.6(1.3) | 3.8 – 12.7 | 7.2(3.3) | 3.3 – 9.8 | n/a | |
| GENERAL | ||||||
| MMSE | 22.0(11.0) | 9 – 26 | 27.0(1.0) | 22 – 27 | 30.0(1.0) | |
| Clinical Dementia Rating Scale | 1.0(1.5) | 0.5 – 2 | 1.0(0.0) | 1 – 2 | 0(0) | |
| CDR Sum of Boxes | 7.0(7.5) | 3 – 11.5 | 8.0(2.5) | 3.5 – 11 | 0(0) | |
| Functional Activities Questionnaire | 25.0(8.0) | 7 – 26 | 20.5(11.0) | 7 – 26 | n/a | |
| Neuropsychiatric Inventory Total | 35.0(7.0) | 18 – 41 | 47.5(19.5) | 36 – 58 | n/a | |
| NPI Distress Total | 12.0(9.0) | 0 – 18 | 20.5 (12.0) | 14 – 27 | n/a | |
| Geriatric Depression Scale (max=30) | 8.0(9.0) | 3 – 19 | 4.0(13.0) | 0 – 13 | 3.0(5.0) | |
| Calculations (max=5) | 2.0(3.0) | 0 – 4 | 5.0(1.0) | 1 – 5 | 5.0(0) | |
| Praxis Testing: | ||||||
| Cough (max = 2) | 2.0(0) | 2 – 2 | 2.0(0.5) | 1 – 2 | 2.0(0) | |
| Blow out a match (max=2) | 2.0(0) | 2 – 2 | 2.0(0.5) | 1 – 2 | 2.0(0) | |
| Praxis Total (max=14) | 14.0(1.5) | 11 – 14 | 13.5(3.0) | 9 – 14 | 14.0(0) | |
| SPEECH & LANGUAGE | ||||||
| Abbrev BNT (max=15) | 14.0(6.0) | 8 – 15 | 15.0(1.0) | 2 – 15 | 15.0(1.0) | |
| D-words/min | 3.0(2.0) | 0 – 11 | 4.0(2.0) | 2 – 10 | 16.0(6.0) | |
| Animals/min | 6.0(4.0) | 0 – 9 | 7.0(2.0) | 5 – 11 | 22.0(7.0) | |
| Syntax Comprehen. (max=7) | 4.0(2.0) | 2 – 4 | 4.0(0.0) | 2 – 4 | 4.0(0.0) | |
| Repetition (max=3) | 3.0(0) | 2 – 3 | 3.0(1.0) | 1 – 3 | 3.0(0) | |
| Write Sentence (pass/fail) | 3/2 | -- | 5/0 | -- | 50/0 | |
| Conversational Speech Ratings (max=4): | ||||||
| Prosody | 4.0(2.0) | 0 – 4 | 4.0(1.0) | 3 – 4 | 4.0(0) | |
| Phrase Length | 4.0(2.0) | 0 – 4 | 4.0(1.0) | 3 – 4 | 4.0(0) | |
| Paraphasic Errors | 4.0(0) | 4 – 4 | 4.0(0) | 4 – 4 | 4.0(0) | |
| Grammar | 4.0(1.5) | 1 – 4 | 4.0(0) | 4 – 4 | 4.0(0) | |
| Comprehension | 4.0(1.0) | 2 – 4 | 4.0(0) | 2 – 4 | 4.0(0) | |
| Word Finding | 4.0(2.0) | 0 – 4 | 4.0(0) | 4 – 4 | 4.0(0) | |
| VISUOSPATIAL | ||||||
| Pentagons (Pass/Fail) | 4/1 | -- | 4/0 | -- | 48/2 | |
| Modif. Rey-O copy (max=17) | 14.0 (2.0) | 12 – 17 | 15.0 (1.0) | 14 – 16 | 16.5(1.5) | |
| VOSP Number Location (max=10) | 7.5 (4.0) | 5 – 10 | 8.0 (3.0) | 6 – 9 | 10.0(1.0) | |
| Cube (max=2) | 1.0(1.0) | 0 – 2 | 2.0(1.0) | 1 – 2 | 2.0(0) | |
| MEMORY | ||||||
| CVLT-MS: | ||||||
| Total All Trials (max=36) | 10.0(12.0) | 5 – 22 | 20.0(12.0) | 9 – 24 | 30.0(6.0) | |
| Corr 30" (max=9) | 2.0(3.0) | 1 – 6 | 6.0(2.0) | 2 – 9 | 8.5(2.0) | |
| Corr 10' (max=9) | 1.0(3.0) | 0 – 4 | 5.0(1.0) | 0 – 8 | 8.0(3.0) | |
| Recog Hits (max=9) | 7.0(5.0) | 1 – 9 | 9.0(1.0) | 7 – 9 | 9.0(0) | |
| Recog False Positives (max=18) | 3.0(3.0) | 0 – 5 | 3.0(2.0) | 0 – 7 | 0(1.0) | |
| Modif. Rey-O 10' delay (max=17) | 6,0(8.0) | 1 – 11 | 6.0(7.0) | 2 – 14 | 13.0(4.5) | |
| Modif. Rey-O 10' delay Recog (pass/fail) | 2/3 | -- | 3/2 | -- | 45/3 | |
| EXECUTIVE/WORKING MEMORY | ||||||
| Span of digits backward | 2.0(5.0) | 0 – 5 | 4.0(1.0) | 0 – 6 | 5.0(2.0) | |
| World Backward (max=5) | 3.0(4.0) | 0 – 5 | 4.0(0.5) | 4 – 5 | 5.0(0) | |
| modified Trailmaking (#lines/min) | 4.5(4.5) | 0.5 – 7.1 | 3.3(2.8) | 2 – 7 | 30.0(20.5) | |