Figure 2.

Simulations of the sensitivity of the two leakage correction methods to variations in the underlying hemodynamics and CA extravasation properties. The solid lines indicate the line of unity. The results are shown for (A) T₂^*-dominant extravasation (E_a=0.1) and (B) T₁-dominant extravasation (E_a=−0.1). In both cases, correction Method II enabled good reproduction of the actual hemodynamic parameters independent of the underlying values of CBV and MTT. Method I resulted in under-estimation of CBV and MTT at high MTT and CBV values. Uncorrected CBV and MTT were over-estimated for T₂^*-dominant leakage and under-estimated for T₁-dominant extravasation effects. CBV, cerebral blood volume; MTT, mean transit time.