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. 2011 Apr 20;31(10):2041–2053. doi: 10.1038/jcbfm.2011.52

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Copyright © 2011 International Society for Cerebral Blood Flow & Metabolism, Inc.

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Pixel-wise analysis of error in K₂ and nCBV as function of nMTT in two sample cases. The left column shows the relationship between K_a and K₂ for pixels with 0.9<nMTT<1.1. A high correlation was observed in both cases confirming the validity of the assumption that K_a and K₂ are linearly related for nMTT values close to unity. The middle column shows the deviation (ΔK₂) from the expected linear relationship between K₂ and K_a as function of nMTT. The right column shows the percentage deviation between normalized corrected CBV values (nCBV) obtained with Method I and nCBV values obtained with Method II (ΔnCBV) as function of nMTT. The resulting dependence of ΔK₂ and ΔnCBV on nMTT was found to be in good agreement with results from simulations as shown in Figure 3. nMTT, normalized mean transit time; nCBV, normalized cerebral blood volume.