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Proposed mechanisms of flow-induced constrictions of cerebral arteries. Increases in flow activate arachidonate production, which is further metabolized by cytochrome P450 4A enzymes (CYP450 4A) into 20-hydroxyeicosatetraenoic acid (20-HETE). CYP450 4A also produces reactive oxygen species (ROS), which contribute to the constriction. The flow-induced constriction is mediated via thromboxane A2/prostaglandin H2 (TP) receptors and requires COX activity.
