Figure 9.

Absence of rhodopsin in the rods in the periphery of an RPE65 postmortem donor eye. Montages of photomicrographs of the periphery tissue from the RPE65 donor (B–E) and control eyes (A) were analyzed using a rhodopsin antibody (B630N). Comparison of the samples showed that rhodopsin was mostly absent in the affected retina in the inferior (B), superior (C), and nasal (E) regions. A few rods were still present in the far periphery of the temporal region of the RPE65 mutant retina (D, inset and arrows). P, periphery; C, central. Scale bar, 500 μm.