Table 1.
Rhabdomyocyte survival at 48 hours. 48hr mean percent survival (±SEM) of non-IR exposed cells, as well as survival of IR-exposed cells receiving P188 alone, PEG alone, cofactor NAC alone as well as combined with P188 or MgATP and P188 with NAC and MgATP.
| Treatment | Baseline | Sham-exposed | 48hrs Post-Radiation (40Gy) | |
|---|---|---|---|---|
| 0hr Control | 48hr Control | No Treatment | Treatment | |
| 1mM P188 | 89.9% ± 1.5 | 83.3% ± 2.2 | 4.8% ± 0.6 | 8.1% ± 1.5a |
| 1mM PEG | 89.9% ± 1.5 | 87.3% ± 3.1 | 6.8% ± 1.0 | 7.1% ± 1.4 |
| 10mM NAC | 89.9% ± 1.5 | 85.3% ± 3.1 | 6.8% ± 1.0 | 13.4% ± 3.8a |
| 1mM P188, 10mM NAC | 86.9% ± 2.1 | 88.0% ± 1.1 | 7.8% ± 1.9 | 31.2% ± 1.1a |
| 10mM NAC, 0.1mM MgATP | 86.9% ± 2.1 | 82.5% ± 1.2 | 5.5% ± 1.6 | 19.9% ± 1.7a |
| 1mM P188, 10mM NAC, 0.1mM MgATP | 86.9% ± 2.1 | 81.7% ± 1.0 | 7.2% ± 1.4 | 29.5% ± 3.0a |
Results are significantly different than irradiated, untreated samples