Table 5.

Analysis of Retinal Protein Expression in Human Glaucoma: Proteins Involved in the Inflammasome

Symbol	Protein Name	RefSeq	Fold Change
NOD1 (CARD4)	Nucleotide-binding oligomerization domain-containing protein 1	NP_006083	2.1*
NOD2 (CARD15)	Nucleotide-binding oligomerization domain-containing protein 2	NP_071445	1.7
NLRC5	Nucleotide-binding oligomerization domain-containing protein 27	NP_115582	1.4
NLRP3 (NALP3)	NACHT, LRR and PYD domains-containing protein 3 isoform b	NP_899632	2.2*
CASP1	Caspase 1 isoform alpha	NP_150634	3.1*

Retinal protein samples obtained from human donor eyes with (n = 10) or without glaucoma (n = 10) were individually analyzed by quantitative LC-MS/MS. All listed proteins were identified with high confidence (greater than 99.0% probability assigned by the Protein Prophet algorithm) based on at least two identified peptides.

^*Significant difference in protein expression between glaucomatous and control samples (Mann-Whitney rank sum test; P < 0.05).