Table 3.
Frequencies of the WDR36 Inferred Haplotypes in Cases and Controls
| Haplotype | POAG1 (%) (n = 249) | Controls (%) (n = 317) | POAG1 vs. Control |
POAG2 (%) (n = 204) | POAG2 vs. Control |
POAG Combined (%) (n = 455) | POAG Combined vs. Control |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| P (P*) | OR (95% CI) | P (P*) | OR (95% CI) | P (P*) | OR (95% CI) | |||||
| H1 (G-A-T-C-A-C) | 42.50 | 37.60 | 0.082 (NS) | NS | 39.60 | NS | NS | 41.30 | NS | NS |
| H2 (A-A-C-T-G-C) | 23.50 | 17.00 | 0.004 (0.012) | 1.50 (1.10–2.03) | 24.00 | 0.004 (0.012) | 1.54 (1.12–2.12) | 23.80 | 0.0008 (0.0024) | 1.53 (1.17–1.99) |
| H3 (G-A-C-C-A-C) | 13.50 | 12.40 | NS | NS | 14.10 | NS | NS | 13.80 | NS | NS |
| Rest of haplotypes | 20.50 | 33.00 | — | NS | 22.30 | — | NS | 21.10 | — | NS |
Haplotypes were constructed with polymorphisms −640G>A, −235A>G, −192C>T, c.IVS5+30C>T, p.I264V, and c.IVS18+217C>T. Only individual haplotypes inferred with a probability >0.7 and with frequencies larger than 7% in at least one of the groups are shown. NS, not significant.
*
Bonferroni corrected (P > 0.1).