Table 7.
Interaction between the WDR36 Haplotypes and the P53 SNP p.R72P [c.215G>C (rs1042522)]
| WDR36 Haplotype/P53 p.R72P Genotype | POAG1 (%) (n = 250) | Controls (%) (n = 323) | POAG1 vs. Control OR (95% CI) | POAG2 (%) (n = 204) | POAG2 vs. Control OR (95% CI) | POAG Combined (%) (n = 455) | POAG Combined vs. Control OR (95% CI) |
|---|---|---|---|---|---|---|---|
| H1/RR | 22.20 | 24.61 | 1.00) | 26.90 | 1.00 | 25.70 | 1.00 |
| H1/RP | 17.00 | 10.99 | 1.89 (0.92–3.87 | 13.70 | 1.27 (0.74–2.30) | 16.70 | 1.42 (0.76–2.67) |
| H2/RR | 13.80 | 12.23 | 1.19 (0.81–1.74) | 13.20 | 1.26 (0.83–1.90) | 14.06 | 1.22 (0.87–1.70) |
| H2/RP | 9.40 | 4.18 | 2.47 (1.28–4.78) | 7.35 | 1.40 (0.69–2.84) | 9.23 | 1.90 (1.07–3.40) |
| H3/RR | 7.60 | 8.51 | 0.88 (0.54–1.43) | 4.44 | 0.69 (0.41–1.17) | 6.59 | 0.79 (0.52–1.20) |
| Rest | 30.00 | 39.48 | — | 34.41 | — | 27.72 | — |
Haplotypes were constructed with polymorphisms −640G>A, −235A>G, −192C>T, c.IVS5+30C>T, p.I264V, and c.IVS18+217C>T. Only individual haplotypes inferred with a probability >0.7 and with frequencies larger than 7% in at least one of the groups are shown.