Table 1.

Demographics of the Study Cohorts

	n		Mean Age (SD)	% Female			Control	P
	Case	Control	Case	Control	P	Case
Discovery (pooled)	97	216	48.4 (15.5)	76.7 (8.5)	<0.001	53.0	28.9	0.002
Rep1	96	72	42.7 (15.1)	72.9 (11.3)	<0.001	38.5	9.9	<0.001
Rep2	215	112	41.2 (14.8)	71.6 (8.5)*	<0.001	39.3	50.1	0.054
Discovery (individual) US1	222	3246	43.8 (13.3)	72.3 (5.4)	<0.001	43.7	39.2	0.188
US2	304	518	42.9 (15.6)	45.4 (13.7)	0.017	31.6	47.7	<0.001
Total	933	4164

Comparisons were made with a t-test for age and χ² test for sex.

^*Age was available only for 68/112 controls in Rep2, and this cohort was not examined.