Skip to main content
. 2011 Jul 18;589(Pt 18):4473–4489. doi: 10.1113/jphysiol.2011.213371

Figure 6. Gap junctions are required for the presence of excitatory ON responses in OFF α-GCs.

Figure 6

A, the typical extracellularly recorded response of an OFF α-GC in the rabbit retina under control conditions. B, application of PTX (100 μm) unmasks a robust ON response in the OFF α-GC. C, application of the gap junction blocker 18β-GA (25 μm) blocks the unmasked ON response, but has no significant effect on the OFF response. D, the ON response returns after washout of 18β-GA. E, the typical response of the OFF α-GC is restored when all drugs are washed out. F, the typical extracellularly recorded response of another OFF α-GC in the rabbit retina under control conditions. G, application of PTX (100 μm) unmasked an ON response at stimulus onset. H, application of the gap junction blocker MFA (100 μm) blocks the unmasked ON response, but has no significant effect on the OFF response. Light intensity of green stimulus = 0.21 Rh* rod−1 s−1.