Table 1.
Sensitivity (EC50) to ACh and SNP
| EC50 | Young | Older |
|---|---|---|
| Acetylcholine | (6.6 ± 2.9) × 10−8 | (41.3 ± 34.9) × 10−8 |
| Acetylcholine + sirtinol | (1.8 ± 1.2) × 10−6* | (12.0 ± 7.7) × 10−6 |
| Acetylcholine + sirtinol +l-NAME | (1.2 ± 0.5) × 10−6 | (1.6 ± 0.8) × 10−6 |
| Sodium nitroprusside | (2.5 ± 1.7) × 10−8 | (1.2 ± 0.2) × 10−8 |
| Sodium nitroprusside + sirtinol | (8.7 ± 5.1) × 10−9 | (22.0 ± 7.2) × 10−9 |
Values are means ± SEM; EC50, acetylcholine dose at which yields 50% vasodilation; l-NAME, NG-monomethyl-l-arginine
*
P < 0.05 vs. Young acetylcholine.