Figure 3. P2Y₁R potentiation of frequency in mouse is spatially restricted to the preBötC.

A, integrated XII nerve (∫XII) recordings from a mouse medullary slice preparation illustrating the effects on inspiratory-related output of locally applying 0.1 mm MRS 2365 (P2Y₁R agonist) at the site of maximum SP sensitivity (hotspot) in the VRC and at sites of varying distance from the hotspot. B, group data illustrating P2Y₁R agonist responses evoked when injections were made at increasing distances from the hotspot in the ventral (n = 5, ○), dorsal (n = 5, ▴) and lateral (n = 5, •) directions. Data are plotted relative to the maximum response evoked at the hotspot. *Significantly different from maximum response. Error bars indicate SEM.