Table 3.
Summary of Mitochondrial DNA Mutations in Ulcerative Colitis Samples
Case number | Gender | Age | Site | Dysplasia | Mutation position | Type | Gene/region | Amino acid change | Notes |
---|---|---|---|---|---|---|---|---|---|
3 | F | 17 | Whole | Y | 352 | A to C | D- loop 2 | MITOMAP (Birket et al., 2009; Reeve et al., 2008) | |
362 | C to A | ||||||||
366 | G to A | ||||||||
372 | T to A | ||||||||
375–376 | CA to AC | ||||||||
379 | A to G | ||||||||
383 | T to A | ||||||||
388–389 | AG to GA | ||||||||
391 | T deletion | ||||||||
411 | C to G | ||||||||
414 | T to G | ||||||||
10 | M | 40 | Whole | Y | 6671 | T to C | CO1 | NS | MITOMAP (Herrnstadt et al., 2002) |
6680 | T to C | NS | MITOMAP (Herrnstadt et al., 2002) | ||||||
6724 | T deletion | FS | |||||||
11 | M | 43 | Left | N | 508 | T insertion | D-loop 1 | ||
12 | M | 45 | Recto-sigmoid | N | 523–52 | Deletion of AC | D-loop 1 | MITOMAP (Wanrooij et al., 2004) | |
13 | M | 50 | Whole | Y moderate | 523–524 | Deletion of AC | D-loop 1 | MITOMAP (Wanrooij et al., 2004) | |
532 | T insertion | ||||||||
539 | T insertion | ||||||||
546 | T insertion |
MITMAP: a polymorphism reported in MITMAP: A Human Mitochondrial Genome Database. 2009 (MITOMAP, 2009).