Table 4.

Summary of Mitochondrial DNA Mutations in Colorectal Cancer Samples

Case number	Gender	Age	Site	Grade	Mutation position	Type	Gene/region	Amino acid change	Notes
1	F	13	Rectum	II	574	A to C	D-loop 1
					576	CCCC insertion			Germline mutation
					584–585	TA to GC
					587	C to T
					591	C to A
					593	T to C			MITOMAP (Mimaki et al., 2009; Gonzalez et al., 2007)
					596	T to C
					601–602	GC to AA
					605–607	TAC to AAA
					612	N insertion
					616	T to G
					618	T del
					622	G to A
					624	C to A
					628	C to G
2	M	27	Rectum	II	489	T to C	D-loop 1		MITOMAP (Mimaki et al., 2009)
					589	T deletion
					12403	C to T	ND5	L to F	MITOMAP (Gonzalez et al., 2007; Mimaki et al., 2009)
14	F	41	Sigmoid	II	6618	C insertion	CO1	FS
					6724	T deletion		FS
16	F	43	Ascending	II	3594	C to T	ND1	V to V	MITOMAP (Mimaki et al., 2009)
25	M	50	Rectum	II	3594	C to T	ND1	V to V	MITOMAP (Mimaki et al., 2009)
29	F	52	Ascending/poly	II	3483	A insertion	ND1	FS
33	M	58	Descending	III	361	A to C	D-loop 2		MITOMAP (Mimaki et al., 2009; Jazin et al., 1996)
					366	G to A
					372	T to A
					376	A to C
					379	A to G			MITOMAP (Mimaki et al., 2009; Feder et al., 2008)
					383	T to A
					388–389	AG to GA
					392	A del
					404	C to T
					411	C to G
					414	T to G			MITOMAP (Birket et al., 2009; Reeve et al., 2008)
35	M	60	Rectum	I	3614	C insertion	ND1	FS
36	F	62	Rectum	II	392	A to C	D-loop 2

MITMAP: a polymorphism reported in MITMAP: A Human Mitochondrial Genome Database. 2009 (MITOMAP, 2009).