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. Author manuscript; available in PMC: 2012 Nov 8.
Published in final edited form as: Vaccine. 2011 Oct 1;29(48):8802–8826. doi: 10.1016/j.vaccine.2011.09.009

Table 3.

Antigen Group Antigen Function in tumor growth and spread Tumor types Naturally occurring antibody in patients Efficacy and safety of passive immunotherapy, animal experiments Vaccination of patients with
Glyco-sphingo-lipids Globo H Related to metastatic spread small cell lung, breast, prostate, lung, colonpancreas, gastric, prostate, ovarian, and endometrial tumors Yes Anti-Globo H made after tumor cell vaccination

  • Breast cancer patients have more naturally occurring anti-Globo H than normal

  • synthetic KLH-conjugated

    Globo H vaccine in breast and prostate cancer patients tolerated and IgM made

  • Globo H-MUC vaccine – safe abs made
SSEA-3 Related to metastatic spread Testicular, lung, breast, teratocarcinoma Yes
Human hybridomas made from lung cancer patient nodes

  • KLH-conjugated Globo H in mice – Ab made