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. Author manuscript; available in PMC: 2012 Nov 8.
Published in final edited form as: Vaccine. 2011 Oct 1;29(48):8802–8826. doi: 10.1016/j.vaccine.2011.09.009

Table 4.

Antigen Group Antigen Function in tumor growth and spread Tumor types Naturally occurring antibody in patients Efficacy and safety of passive immunotherapy, animal experiments Vaccination of patients with
Ganglio-sides GD2 tumor cell attachment to matrices Neuroblastoma Monoclonal antibody caused sensorimotor polyneuropathy nerve demyelination

  • bovine derived or synthetic fucosyl GM1-no antibody made

  • GD2 injected with the adjuvant QS-21- antibody was made
GD3 a role in the regulation of cell growth angiogenesis tumor cell attachment to matrices melanoma small-cell lung cancer patients a pulmonary capillary leak occurred at high antibody dose,

  • GD3-KLH with QS21

  • anti-idiotypic antibody BEC2, a mimic of GD3 plus BCG

  • BEC2 followed by the GD3-KLH. 10 patients made oanti-GD3 antibody

  • BEC2 + BCG in 515 patients had no effect
GM2 a role in cellular interactions and adhesion melanoma small-cell lung cancer 5% of melanoma patients have anti- GM2 antibodies, and the presence of these antibodies is related to longer disease free survival

  • GM2 was injected along with BCG

    • Patients made AB but no difference in disease free survival

  • GM2-KLH immunization using the adjuvant QS21 in one treatment arm with high dose interferon alpha-2b

    • Interferon better

  • GM2-KLH conjugate worse than observation alone
Fucosyl GM1 small-cell lung cancer patients with sensory nerve pathology have anti- Fucosyl GM1 Monoclonal antibody protective in animal experiments

  • bovine derived or synthetic fucosyl GM1 resulted in antibody production