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. Author manuscript; available in PMC: 2012 Nov 8.
Published in final edited form as: Vaccine. 2011 Oct 1;29(48):8802–8826. doi: 10.1016/j.vaccine.2011.09.009

Table 5.

Antigen Group Antigen Function in tumor growth and spread Tumor types Naturally occurring antibody in patients Efficacy and safety of passive immunotherapy, animal experiments Vaccination of patients with
Additional Sialic acid containing NeuGcGM3 Decrease CD4 T cell response Colon, breast, melanoma, small cell lung cancer, neuroblastoma, germ cell tumors Hanganutziu-Deicher antibodies These are related to serum sickness Minimal side effects

  • Anti-idiotypic antibody called racotuomab

  • Proteoliposome with NeuGcGM3 and Neisseria meningitidis external membrane complex
Polysialic acid linked to NCAM Blocks cell-cell interactions Related to cell growth and metastasis small cell lung carcinoma rhabdo-myosarcoma, Wilms’ tumor, neuroblastoma glioblastoma multiforme Autoimmunity to brain possible but not seen

  • N-propionylated-PSA

  • PSA-KLH