Figure 2.

Transposition within the T-cell lineage does not show significant integration site bias. (A) The distribution of insertion sites within nonmalignant thymocytes and tumors from the Vav-SB and CD4-SB models is shown. A Fisher exact test was used to compare the distribution in each sample to the expected distribution observed in the mouse genome. (B) A Pearson correlation revealed a positive correlation between the number of insertion events within each RefSeq gene and the number of TA sites (ie, SB target sites) found within the gene. However, this correlation is present in nonmalignant control samples (circles) but not in tumor samples (squares).