Table 3.

Comparison of driver mutations to COSMIC and CGC databases

Model	No. of driver genes also mutated in COSMIC or CGC*	P
Vav-SB	11 of 22 (Notch1, Ikzf1, Akt2, Erg, Runx1, Crebbp, Foxp1, Akt1, Flt3, Myc, Sik3)	2.7 × 10−10
Lck-SB	17 of 36 (Whsc1, Jak1, Myc, Akt1, Foxp1, Pten, Brd4, Ikzf1, Ncoa2, Smg6, Akt2, Birc6, Cblb, Crebbp, Irf4, Mllt3, Tsc1)	1.07 × 10−14
CD4-SB	21 of 37 (Myc, Akt2, Jak1, Whsc1, Ncoa2, Setd2, Ccnd3, Brd4, Cdkn2a, Chd9, Crebbp, Foxp1, Hipk2, Irf4, Picalm, Fyn, Nsd1, Pik3r1, Ptpn22, Raf1, Smg6)	4.76 × 10−20

^*The COSMIC and CGC databases currently have data on the mutation frequencies for 18 661 nonredundant genes. Of these, 15 631 have identified mouse orthologues that have also been evaluated by both Monte Carlo and gCIS approaches. We determined the number of driver mutations from each tumor model identified by these methods that have 4 or more independent mutations in the COSMIC database or are present in the CGC database. A Fisher exact test was then performed to determine the significance of the observed overlap.