Table 1.
Lipid and hematologic parameters in apoE−/− mice treated with PRT060318
| Parameter | Vehicle control (n = 4) | PRT060318 (n = 5) | P |
|---|---|---|---|
| Lipids | |||
| Total cholesterol, mg/dL | 334 ± 64 | 378 ± 96 | 0.44 |
| LDL cholesterol, mg/dL | 319 ± 61 | 334 ± 64 | 0.58 |
| Triglycerides, mg/dL | 44 ± 16 | 51 ± 11 | 0.48 |
| CBC | |||
| WBC, no./μL × 103 | 3.7 ± 1.1 | 3.8 ± 1.4 | 0.94 |
| Hemoglobin, g/L | 10.8 ± 2.1 | 12.4 ± 1.9 | 0.25 |
| Platelet count, no./μL × 103 | 577 ± 297 | 480 ± 136 | 0.58 |
PRT060318 (30 mg/kg in distilled water) or vehicle control was administered via oral gavage twice daily for 3 weeks followed by 1 week off, for a total of 16 weeks.
LDL indicates low-density lipoprotein; CBC, complete blood count; WBC, white blood cells; PMN, neutrophils; and HCT, hematocrit.