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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Bioorg Med Chem. 2006 Oct 26;15(2):759–770. doi: 10.1016/j.bmc.2006.10.051

Figure 3.

Figure 3

Postulated hydrogen-bonding models for the 1:1 polyamide-DNA complexes with their matched sequence and the ball-and-stick representation for compounds 1 and 6 over the 6-base-pair matched binding site (variable region W = A or T). a) Im-Im-Im-Im-γ-Py-Py-Py-Py-β-Dp (1); b) Im-Im-Im-Im-γ-Py-Bi-Py-Bi-β-Dp (2), Im-Im-Im-Ip-γ-Py-Bi-Py-Bi-β-Dp (3), Im-Im-Ip-Im-γ-Py-Bi-Py-Bi-β-Dp (4), Im-Ip-Im-Im-γ-Py-Bi-Py-Bi-β-Dp (5), Im-Ip-Im-Ip-γ-Py-Bi-Py-Bi-β-Dp (6).