Table 6. We tabulate the ASB SNPs proximal to genes (within 2.5 kb of the TSS to the TTS of the gene) containing ASE SNPs.
| Maternal binding | Paternal binding | |
|---|---|---|
| For genes that contain multiple ASB or ASE SNPs, we select the SNP with the greatest significance for each. We separately tabulate binding sites that exhibit either maternal or paternal ASB against genes that have maternal or paternal ASE. We do this separately for Pol II and Pol III, CTCF, and the remaining transcription factors combined. Using a Fisher's exact test, we see a significant coordination between Pol II & Pol II ASB versus ASE (P-value=1.4e−3) and between the other TFs showing ASB versus ASE (P-value=9.3e−5). We do not observe significant coordination between CTCF ASB and proximal ASE, which is expected given the role of CTCF as an insulator. | ||
| ASB for Pol II and Pol III versus ASE | ||
| Maternal expression | 35 | 5 |
| Paternal expression | 7 | 19 |
| ASB for transcription factors combined (excluding CTCF) versus ASE | ||
| Maternal expression | 14 | 6 |
| Paternal expression | 2 | 19 |
| ASB for CTCF versus ASE | ||
| Maternal expression | 8 | 10 |
| Paternal expression | 4 | 6 |